Mark Cuban’s Cost Plus Drugs is now integrated with President Trump’s TrumpRx platform, allowing patients to access hundreds of generic medications through the government’s direct-to-consumer drug pricing tool. In May 2026, TrumpRx expanded to include more than 600 generic drugs, with Cost Plus Drugs serving as one of three main partners alongside Amazon Pharmacy and GoodRx.
Cuban announced the partnership at the HLTH conference in Las Vegas in October 2025, revealing that Cost Plus Drugs would share its application programming interface and pricing data with TrumpRx. When users search for generic medications on TrumpRx, the site directs them to Cost Plus Drugs’ platform, which sells medications directly to consumers at cost plus a 15% markup.
The expansion represents a significant step for TrumpRx, which launched in February 2026 with dozens of brand-name discounted drugs. By adding over 600 generics through partnerships with Mark Cuban’s company and others, the platform nearly sevenfold increased its product offerings. Cuban has long argued that pharmacy benefit managers, or PBMs, artificially inflate drug prices, and Cost Plus Drugs aims to bypass that middleman system entirely.
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Sources
- Healthcare Dive — Mark Cuban’s announcement of the Cost Plus Drugs partnership with TrumpRx at HLTH 2025, details on how the partnership works, and Cuban’s criticism of PBMs
- AP News — President Trump’s announcement of more than 600 generic medications being added to TrumpRx in May 2026
- CNBC — Trump’s announcement of adding generic drugs to TrumpRx with expansion details
- The White House — Official fact sheet on TrumpRx expansion with Mark Cuban partnership details
